Nef Antikörper (FITC)

Produktnummer ABIN933664

Dieser Maus Monoklonal Antikörper erkennt spezifisch in WB und ELISA. Er zeigt eine Reaktivität gegenüber Human Immunodeficiency Virus (HIV).

Kurzübersicht für Nef Antikörper (FITC) (ABIN933664)

Target: Nef

Reaktivität: Human Immunodeficiency Virus (HIV)

Wirt: Maus

Klonalität: Monoklonal

Konjugat: FITC

Applikation: Western Blotting (WB), ELISA

Klon: 2H12 N-terminus

Produktdetails

Kreuzreaktivität (Details): Reacts with recombinant nef in ELISA and WB.

Reinheit: > 95 % pure

Immunogen: HIV1 Nef antibody (FITC) was raised using purified recombinant nef (HIV-1) produced in E.coli expression system as the immunogen.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: ELISA: 1:1,000, WB: 1:1,000
Optimal conditions should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Konzentration: Lot specific

Buffer: Supplied lyophilized in PBS buffer.

Handhabung: Avoid repeated freeze/thaw cycles.
Product is photosensitive and should be protected from light.
Dilute only prior to immediate use.

Lagerung: -80 °C

Informationen zur Lagerung: Aliquot and store at -70 °C or lower.

Antigendetails

Target: Nef

Substanzklasse: Viral Protein

Hintergrund: Nef is a early protein that may play a role in optimizing the host cell environment for viral replication without causing apoptosis. Nef enhances virus infectivity and pathogenicity. It down regulates surface MHC I molecules and internalized molecules are sequestered to the trans-Golgi network. The number of cell surface CD4 antigen are decreased by interacting with the Src family kinase LCK thereby inducing LCK CD4 dissociation and by increasing clathrin-dependent endocytosis of this antigen to target it to lysosomal degradation.  . Synonyms: Monoclonal HIV1 Nef antibody, Anti-HIV1 Nef antibody, HIV-1 Nef antibody, 3'ORF antibody, ABIN antibody, ABIN1 antibody,C terminal core protein antibody, F protein antibody, Nef antibody, Negative factor antibody, p27 antibody, VAN antibody.